Impact of Capsules as a Carrier for Multiple Unit Drug Delivery and the Importance of HPMC Capsules

Multiple unit dosage forms are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some desired characteristics. It is even possible to include a number of dosage forms - such as tablets, pellets, capsules, powders and granules - within a single formulation. In this way, incompatibilities and interaction between the different drug substances in combination products can be prevented. Hard gelatin capsules are particularly suitable for their development and manufacture. Hard gelatin capsules do have some drawbacks. To overcome these problems, pharmaceutical scientists have developed capsules made of starch, cellulose derivatives and polyvinyl alcohol copolymer. To date, HPMC capsules have been successfully utilized for pharmaceutical products.

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