Twenty-one
local domestic rabbits were divided into three groups each group had special
dietary regimen for 8 weeks: Group I (normal control), Group II (atherogenic
control) and Group III (2% Cholesterol + aliskiren 40mg/kg/day orally). Blood
samples were collected at the end of experiment (8 weeks) for measurement of
serum lipid profile, plasma high sensitive C-reactive protein (hs-CRP), plasma
malondialdehyde (MDA) and plasma reduced glutathione (GSH). Immunohistochemical
analysis including vascular cell adhesion molecule-1 (VCAM-1); monocyte
chemoattractant protein-1 (MCP-1); tumor necrotic factor - α (TNF-α); and
interleukin – 17 (IL-17). Histopathologic assessment of aortic atherosclerotic
changes were also performed.
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