Development of Aceclofenac Nanosuspension Stabilized by Poly vinyl alcohol and Sodium dodecyl sulphate

Nanosuspensions were prepared by precipitation-ultrasonication method. PVA along with an anionic surfactant delivered a nanosuspension with narrow polydispersity index successfully. Polymer to drug ratio and concentration of sodium dodecyl sulphate (SDS) significantly influenced the particle size of nanosuspension. SDS showed a synergistic effect with PVA and dramatically affected the physical characteristics of formulations. Nanosuspensions were evaluated for saturation solubility, in vitro drug dissolution behavior, particle size, polydispersity index, zeta potential, crystallinity (DSC) and surface morphology (FESEM).All formulations were found with higher saturation solubility compared to raw drug.

Website: http://www.arjonline.org/medicine-and-health-care/american-research-journal-of-pharmacy/